CODesign: Consistency from Data to Trajectory in All-Atom Protein Binder Co-Design

arXiv:2610.01773v1 Announce Type: cross Abstract: The central challenge in de novo protein design is generating plausible, mutually compatible structures and sequences, such that each designed sequence folds into its intended structure and the structure accommodates that sequence. Compared to typical two-stage design methods, which decouple the modeling of the interdependent modalities, co-design models improve the cross-modal consistency by jointly generating sequences and structures. However, naively generating sequences and structures simultaneously does not ensure their consistency. To add

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