arXiv — cs.AI preprintsInternational9 October 2026
La-Ribo: RNA Co-Design via Geometry-Latent Flow Matching
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arXiv:2610.12236v1 Announce Type: cross Abstract: RNA function arises from the coupling of nucleotide sequence and three-dimensional structure, motivating their joint design. Coordinating global folding with nucleotide-level detail remains challenging under limited structural supervision. We introduce La-Ribo, a generative framework for RNA sequence-structure co-design via geometry-latent flow matching. La-Ribo retains a sparse phosphate-sugar--base scaffold and encodes nucleotide identity and local conformation in residue-wise latents. A shared flow network generates both jointly, and an RNA-
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