arXiv: cs.AI preprintsInternational6 November 2026
MUSS: A Multi-scale and Sequence-based Model for Single-cell Gene Regulation
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arXiv:2611.08086v1 Announce Type: new Abstract: Modeling gene regulation in single cells requires jointly representing DNA sequence, chromatin accessibility, and gene expression across regulatory scales. Sequence-based models capture DNA-level regulatory grammar but often lack cell-level resolution, whereas many single-cell omics models represent genes and peaks as fixed-vocabulary tokens without their underlying sequence. Here, we present MUSS, a sequence-based multi-scale model for single-cell gene regulation that preserves both DNA-level and cell-level resolution. MUSS derives peak- and gen
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