VGL-stGen: Learning a shared multimodal model for lung histology and spatial transcriptomics

arXiv:2610.28266v1 Announce Type: cross Abstract: VGL-stGen is a multimodal large language model adapted from a pretrained medical vision-language model using paired lung H&E and spatial transcriptomics with single-cell references. Training integrates image-expression and expression-cell-type pairs, and gene-conditioned pseudo-labels transfer transcriptomic cell-type supervision to histology images. One deployed checkpoint supports thirteen evaluated tasks spanning tissue and cell-type classification, gene prediction and conditional expression completion from combinations of histology, cell id

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