Sesame (Success by Sesame) Review 2026: Budget-conscious patients who want labs and live video visits included in a low program fee
Our verdict
Success by Sesame is one of the cheaper full-service programs: $99/month billed monthly or $59/month on an annual plan, and unlike most rivals the subscription includes lab work alongside video visits and messaging. Sesame accepts insurance for medications, and cash-pay prices track manufacturer direct rates: Wegovy pill $149-$299/month, Wegovy pen $349/month standard self-pay after a $199 introductory period, Zepbound KwikPen $299-$698/month by dose, and the new oral GLP-1 orforglipron (Foundayo) from $149/month. Because Sesame is a marketplace, clinicians set their own visit prices, so your actual subscription rate can vary by provider, and continuity depends on who you book. Note that the site's FAQ still describes an introductory Wegovy offer whose stated terms ran through June 30, 2026. In SURMOUNT-1, tirzepatide produced up to 20.9% mean body-weight reduction at 72 weeks at the 15 mg dose; that is medication trial data, not a Sesame outcome. Prescriptions always require a licensed clinician's evaluation.
Score breakdown
- Safety (30%)8.0/10
- Evidence (30%)8.5/10
- Cost & Value (20%)9.0/10
- Transparency (10%)8.0/10
- Support (10%)6.5/10
Scored per our review methodology.
Who it's for
Best for: Budget-conscious patients who want labs and live video visits included in a low program fee.
Pricing
$99/mo program ($59/mo with annual plan) incl. labs and video visits + medication: Wegovy pill $149-$299/mo, Wegovy pen $349/mo standard self-pay, Zepbound KwikPen $299-$698/mo
| Plan | Price | Notes |
|---|---|---|
| Success by Sesame program | $99/mo month-to-month; $59/mo with annual plan | Video visits, unlimited messaging, and labs included; clinicians set their own prices so rates can vary |
| Wegovy, cash-pay | Pill $149/mo (1.5/4 mg) or $299/mo (9/25 mg); pen $199/mo first two months, then $349/mo | Intro pen offer terms listed as valid through June 30, 2026; with insurance as low as $25/mo |
| Zepbound KwikPen / Foundayo (orforglipron), cash-pay | Zepbound $299-$698/mo by dose; Foundayo $149-$349/mo by dose | Dose-tiered LillyDirect-aligned pricing; prescription required |
What the evidence says
- Tirzepatide produced mean body-weight reductions of 15.0-20.9% at 72 weeks across the 5-15 mg doses in the SURMOUNT-1 randomized trial. (SURMOUNT-1 trial (NEJM 2022): Tirzepatide Once Weekly for the Treatment of Obesity)
- Semaglutide 2.4 mg weekly produced a 14.9% mean body-weight reduction at 68 weeks versus 2.4% for placebo in STEP 1. (STEP 1 trial (NEJM 2021): Once-Weekly Semaglutide in Adults with Overweight or Obesity)
- Tirzepatide is available only by prescription, and treatment requires medical evaluation and supervised dose titration. (MedlinePlus: Tirzepatide Injection)
Pros & cons
Pros
- Labs are included in the program fee, which is rare among GLP-1 telehealth programs
- Synchronous video visits with a dedicated clinician rather than questionnaire-only intake
- Insurance accepted for medications, with copays as low as $25/month for covered patients
- Cash-pay medication prices published per dose and aligned with NovoCare/LillyDirect direct rates
- Offers the newest FDA-approved oral GLP-1, orforglipron (Foundayo), from $149/month
Cons & red flags
- Red flag: Sesame is a marketplace where clinicians set their own prices, so the advertised $59-$99/month rate is a floor, not a guarantee, and care continuity depends on the individual provider you book
- Annual plan needed for the lowest $59/month rate; month-to-month costs $99
- Site FAQ still cites an introductory Wegovy/Ozempic pricing offer whose stated terms expired June 30, 2026, so confirm current pricing before enrolling
- Higher Zepbound doses reach $698/month cash-pay, among the priciest tiers in this directory
How it compares
Sesame (Success by Sesame) scores 8.2/10 in our weight loss evaluation. See where it lands in the full ranking: Best Weight-Loss Supplements of 2026.
- Ro (Ro Body) review — 8.4/10, cash-pay patients who want branded glp-1s at manufacturer direct rates with insurance-coordination help
- WeightWatchers Clinic (WW Med+) review — 8.3/10, insured patients who want hands-on prior-authorization help plus a structured behavioral program
Frequently asked questions
How much is the Sesame weight loss program?
The Success by Sesame subscription starts at $59/month with an annual plan or $99/month billed monthly, and includes video visits, messaging, and labs. Medication is separate: for example, cash-pay Wegovy pills run $149-$299/month and Zepbound KwikPens $299-$698/month depending on dose.
Does Sesame include lab work?
Yes. Lab testing to monitor your treatment is included in the Success by Sesame subscription fee, which most competing GLP-1 telehealth programs do not offer.
How much is Zepbound through Sesame?
Without insurance, the Zepbound KwikPen through Sesame is $299/month at 2.5 mg, $398/month at 5 mg, $499/month at 7.5 mg, and $698/month at 10-15 mg. With insurance it can be as low as $25/month. A clinician must prescribe it after evaluating your eligibility.
Does Sesame prescribe compounded semaglutide?
Sesame's weight-loss program lists FDA-approved medications: Wegovy pill and pen, Ozempic, Zepbound, and Foundayo (orforglipron). It is not built around compounded GLP-1s.
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