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arXiv — cs.AI preprintsInternational16 October 2026

A primer on evaluation methods for large language models in healthcare

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arXiv:2609.14819v3 Announce Type: replace-cross Abstract: Large language models (LLMs) have a growing range of applications in medicine, and their evaluation is critical for ensuring they provide benefit and not harm. This evaluation can be more challenging than traditional machine learning for many reasons, including probabilistic and open-ended outputs, and behavior that shifts with prompt design and accumulated context. This review covers four key areas of LLM evaluation: principles of study design, statistical methods, capability evaluation and clinical application evaluation. Capability e
— arXiv — cs.AI preprints

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