Bridging Graph and Pairwise Learning for Gene Regulatory Network Inference from scRNA-seq Data

arXiv:2611.13801v1 Announce Type: cross Abstract: Motivation: Gene regulatory networks (GRNs) capture the underlying interactions through which transcription factors (TFs) regulate genes. Based on gene expression data, existing GRN inference approaches generally fall into two categories: graph-based methods, which model the GRN as a whole graph, and pairwise-based methods, which decompose the GRN into individual TF-target gene pairs for modeling. However, each approach exhibits limitations that are precisely the strengths of its counterpart. Graph-based methods tend to overfit due to their rel

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